Inflammatory Resolution
Gene co-expression module in Neutrophils
| Category | Stress |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
NR4A3 is a nuclear receptor induced in activated myeloid cells and promotes anti-inflammatory resolution. CREM (ICER isoform) is a cAMP-driven transcriptional repressor of inflammatory genes. ZC3H12A (Regnase-1/MCPIP1) is an endonuclease that degrades inflammatory cytokine mRNAs. KDM6B (JMJD3) is a demethylase that activates inflammatory and stress response genes but also promotes anti-inflammatory macrophage polarization. DDIT4 (REDD1) inhibits mTOR under stress. ATG2A drives autophagy. FOSL2 (FRA-2, AP-1) and JOSD1 (deubiquitinase) modulate transcriptional and proteostatic responses. GPR65 is a proton-sensing GPCR active in acidic inflammatory microenvironments. BTG1 is an anti-proliferative, differentiation-promoting gene. The module captures a stress-induced transcriptional reprogramming program with resolution/anti-inflammatory features.
Genes
ARL5B, ATG2A, ATP2B1, BTG1, CREM, DDIT4, FOSL2, GPR65, JOSD1, KDM6B, NR4A3, VPS37B, ZC3H12A
Most correlated modules
- Inflammasome IL-1 Response · correlation 0.87
- Neutrophil Adhesion Signaling · correlation 0.81
- NF-κB Activation · correlation 0.77
- Myeloid Inflammatory Activation · correlation 0.65
- Neutrophil Survival Program · correlation 0.63
- Chemokine Secretion · correlation 0.62
- Immediate Early Response · correlation 0.61
- NF-κB Inflammatory Transcription · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.