HIF1A hypoxia glycolysis
Gene co-expression module in Neutrophils
| Category | Tissue adaptation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 37 genes have a known function matching the annotation |
Why this annotation
This is a classic HIF-1α hypoxia signature with core coherence. It combines glycolytic enzymes (HK2, TPI1, ENO1, GAPDH, LDHA), HIF targets (NDRG1, ERO1A, P4HA1, BNIP3, BNIP3L, HILPDA, PLIN2, FAM210A) and the autophagy/mitophagy gene MAP1LC3B. This fits neutrophils in the physiologically hypoxic colonic mucosa, especially at inflamed sites.
Genes
Most correlated modules
- Hypoxic glycolysis satellite · correlation 0.88
- Mature quiescent neutrophil · correlation 0.82
- Endolysosomal trafficking · correlation 0.79
- Tissue-activated inflammatory neutrophil · correlation 0.78
- HMOX1 Oxidative Stress · correlation 0.73
- Generic housekeeping background · correlation 0.73
- TLR/cytokine receptor activation · correlation 0.67
- Endolysosomal V-ATPase · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.