Specific Granule Release
Gene co-expression module in Neutrophils
| Category | Degranulation |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
MMP9 (matrix metalloproteinase-9) is a key neutrophil gelatinase stored in specific granules and released upon activation, mediating ECM degradation. CA4 (carbonic anhydrase 4) is expressed in mature neutrophils and involved in pH regulation. BMX is a tyrosine kinase activated downstream of PI3K in neutrophils promoting survival and activation. CLEC4D is a C-type lectin receptor on myeloid cells involved in pathogen recognition. CKAP4 is a cytoskeleton-associated membrane protein. VIM (vimentin) is an intermediate filament upregulated in activated neutrophils. GPAT3 is involved in lipid biosynthesis. This module reflects neutrophil specific granule release and matrix remodeling.
Genes
BMX, CA4, CKAP4, CLEC4D, GPAT3, KBTBD7, MMP9, VIM
Most correlated modules
- NET Priming State · correlation 0.84
- Pentose Phosphate Pathway · correlation 0.80
- S100 Alarmin Response · correlation 0.75
- Actin Cytoskeleton Dynamics · correlation 0.72
- Neutrophil Differentiation · correlation 0.71
- Neutrophil Motility Cytoskeleton · correlation 0.63
- Secondary Granule Antibacterial · correlation 0.52
- Endocytic Vesicular Trafficking · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.