Mitotic Spindle
Gene co-expression module in Neutrophils
| Category | Cell cycle |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
Top hub genes include TUBA1B and TUBB (alpha/beta tubulins essential for mitotic spindle), STMN1 (stathmin, a microtubule-destabilizing protein upregulated in proliferating cells), H2AZ2 (histone variant enriched at active promoters during cell cycle), ANP32E and ANP32B (histone chaperones linked to cell cycle chromatin remodeling), NUCKS1 (nuclear casein kinase substrate active in S-phase), H4C3 (core histone H4 required for DNA replication). DEK and HMGB1 are chromatin-associated proteins also upregulated in cycling cells. This is a canonical proliferating cell signature consistent with neutrophil precursors/promyelocytes in division.
Genes
ANP32B, ANP32E, DEK, H2AZ2, H4C3, HMGB1, HNRNPH1, HP1BP3, NUCKS1, SRSF10, STMN1, TUBA1B, TUBB
Most correlated modules
- Primary Granule Antimicrobial · correlation 0.91
- Translation Initiation · correlation 0.85
- S-G2-M Cell Cycle · correlation 0.84
- Proteostasis RNA Metabolism · correlation 0.80
- mRNA Splicing Processing · correlation 0.73
- Immature Neutrophil Granule · correlation 0.73
- RNA Splicing · correlation 0.69
- Translational Housekeeping · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.