Ubiquitin-Proteasome Turnover
Gene co-expression module in Neutrophils
| Category | Housekeeping |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 19 genes have a known function matching the annotation |
Why this annotation
The module contains multiple ubiquitin-proteasome pathway components (FBXO33, FBXL20 as SCF E3 ligase F-box proteins; USP4 deubiquitinase), microtubule/motor proteins (KIF13A kinesin, CLIP1 cytoplasmic linker), RB1CC1 (autophagy initiation), LMTK2 and REPS2 (endosomal trafficking kinase and endocytic adaptor), and signaling regulators (STK17B, NFAM1, IL18RAP). The dominant theme linking the highest-ranked genes is ubiquitin-mediated protein turnover and proteasomal degradation, with accessory roles in intracellular trafficking. As a neighbor to M15 (vesicular trafficking), shared intracellular sorting programs may explain co-expression. The F-box proteins and USP4 dominate the functional signature.
Genes
BLTP3B, CACUL1, CLIP1, FBXL20, FBXO33, FGD3, IL18RAP, KIF13A, LMTK2, MGAM, NFAM1, PHF12, PHTF1, RB1CC1, REPS2, STK17B, USP4, WDR26, ZDHHC20
Most correlated modules
- Endosomal Vesicle Trafficking · correlation 0.94
- Stress Kinase Signaling · correlation 0.94
- Actin Cytoskeletal Remodeling · correlation 0.94
- Granulopoiesis Transcriptional · correlation 0.94
- PI3K Migration Signaling · correlation 0.93
- Endosomal Vesicle Trafficking · correlation 0.93
- Signal Attenuation · correlation 0.93
- Cytoskeletal Remodeling · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.