Translational Housekeeping
Gene co-expression module in Neutrophils
| Category | Housekeeping |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by translation elongation factors (EEF1A1, EEF1B2), ribosome-associated proteins (RACK1, NPM1, UBA52), mRNA stabilization factor (YBX1), glutathione transferases (GSTP1, MGST1), and a mitochondrial subunit (COX4I1). All genes show uniform expression with core coherence, consistent with constitutive translational housekeeping activity. No subset specificity and no inflammatory or stress-specific signal beyond baseline.
Genes
COX4I1, EEF1A1, EEF1B2, GSTP1, MGST1, NPM1, RACK1, UBA52, YBX1
Most correlated modules
- Translation Initiation · correlation 0.90
- Primary Granule Antimicrobial · correlation 0.71
- Mitotic Spindle · correlation 0.69
- Immature Neutrophil Granule · correlation 0.58
- Proteostasis RNA Metabolism · correlation 0.55
- RNA Splicing · correlation 0.55
- Glycolytic Metabolism · correlation 0.52
- mRNA Splicing Processing · correlation 0.45
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.