TLR2 Innate Signaling
Gene co-expression module in Neutrophils
| Category | Innate immunity |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
TLR2 is the key anchor gene — a pattern recognition receptor central to innate immune detection of bacterial components in neutrophils. MAP4K4 and MKNK1 are downstream MAPK pathway kinases activated by TLR signaling. CYRIA activates Rac GTPase downstream of innate immune signals. AATK, STK40 are kinases. ECE1, CHST15, SYTL3, ERGIC1 are more peripheral. The module reflects TLR2-initiated innate immune signaling with MAPK cascade activation, consistent with neutrophil antibacterial response.
Genes
AATK, CHST15, CYRIA, DHX34, ECE1, ERGIC1, MAP4K4, MKNK1, STK40, SYTL3, TLR2, TMCC3, TMEM71
Most correlated modules
- Endocytic Vesicle Trafficking · correlation 0.96
- PI3K Chemotaxis Signaling · correlation 0.95
- Granulopoiesis Transcriptional · correlation 0.92
- Endosomal Vesicle Trafficking · correlation 0.91
- PI3K Migration Signaling · correlation 0.90
- Neutrophil Survival FOXO-MK2 · correlation 0.90
- Mature Neutrophil Identity · correlation 0.89
- Ubiquitin Regulatory Signaling · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.