Stress Kinase Signaling
Gene co-expression module in Neutrophils
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
This core-coherence module of 11 genes uniformly expressed across neutrophil subsets is enriched for stress-activated kinases and ubiquitin-proteasome components. MAP3K5 (ASK1) is a key apoptosis signal-regulating kinase activated by oxidative stress and inflammation; MEF2A is a transcription factor downstream of p38 MAPK and calcium signaling, often activated during stress; HIPK3 is a homeodomain-interacting protein kinase involved in apoptosis and stress signaling; IGF1R is a receptor tyrosine kinase with survival/anti-apoptotic roles; UBR2 is an E3 ubiquitin ligase (N-end rule pathway); PARP8 is a poly-ADP-ribose polymerase with roles in DNA damage/stress; TBC1D1 is a Rab GTPase-activating protein involved in vesicle/metabolic regulation; NEK7 is a NLRP3 inflammasome-activating kinase and mitotic kinase; ANKRD44 is a PP6 regulatory subunit (phosphatase); APBB1IP (RIAM) links integrin activation to the actin cytoskeleton; RAP1GAP2 is a Rap1 GTPase-activating protein relevant to integrin signaling in neutrophils. The combination of MAP3K5, MEF2A, HIPK3, and NEK7 points to a stress-kinase/apoptotic signaling program. Neighbor context (M30 cytoskeletal, M19 vesicular trafficking) and uniform expression suggest a shared homeostatic/regulatory neighborhood rather than acute activation, but the kinase content implies a basal stress-response surveillance program in neutrophils.
Genes
ANKRD44, APBB1IP, HIPK3, IGF1R, MAP3K5, MEF2A, NEK7, PARP8, RAP1GAP2, TBC1D1, UBR2
Most correlated modules
- Actin Cytoskeletal Remodeling · correlation 0.98
- Signal Attenuation · correlation 0.98
- ER Stress Response · correlation 0.97
- Endosomal Vesicle Trafficking · correlation 0.95
- ELMO-DOCK Chemotaxis · correlation 0.95
- JAK-MAPK Signaling · correlation 0.95
- Granulopoiesis Transcriptional · correlation 0.94
- Ubiquitin-Proteasome Turnover · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.