Innate DNA Sensing ISG
Gene co-expression module in Neutrophils
| Category | Antiviral |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
SP110 (nuclear body component, IFN-induced antiviral), TNFSF10 (TRAIL, IFN-induced apoptosis/antiviral), TRIM22 (E3 ubiquitin ligase, ISG, antiviral restriction), IFI16 (IFN-gamma inducible protein 16, innate DNA sensor), RNF213 (IFN-induced E3 ligase, antiviral), AIM2 (absent in melanoma 2, cytosolic DNA sensor/inflammasome), IRF2 (interferon regulatory factor 2), GIMAP4 (GTPase of immune-associated protein, lymphocyte survival but IFN-regulated). This module is dominated by interferon-stimulated genes with a strong innate DNA sensing/antiviral restriction flavor distinct from M28 (which focuses on MX2/GBP-type ISGs). The co-expression with AIM2 and IFI16 highlights a DNA-sensing arm of the IFN response. Neighbor context: M28 and M38 together form a broad ISG neighborhood, but M38 is specifically enriched for innate DNA sensors and TRAIL-mediated antiviral apoptosis.
Genes
AIM2, GIMAP4, IFI16, IRF2, RNF213, SHISA5, SP110, TMEM154, TNFSF10, TRIM22
Most correlated modules
- Neutrophil Chemotaxis Receptors · correlation 0.83
- TLR Lipid Signaling · correlation 0.79
- Mature Neutrophil Identity · correlation 0.78
- Bacterial Phagocytosis Program · correlation 0.78
- Interferon Stimulated Genes · correlation 0.75
- Neutrophil Motility Cytoskeleton · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.