Neutrophil Adhesion Signaling
Gene co-expression module in Neutrophils
| Category | Migration & adhesion |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
LCP2 (SLP-76) is a critical scaffold in myeloid and lymphoid cell activation signaling downstream of immune receptors. ETS2 is a myeloid transcription factor activated by inflammatory stimuli. ICAM1 (CD54) is a key neutrophil adhesion molecule upregulated during inflammation. PDE4B degrades cAMP and is a major regulator of neutrophil inflammatory activation (target of rolipram). SKIL (SnoN) modulates TGF-β/AP-1 signaling. The module is small and tightly core-coherent, likely representing a neutrophil adhesion and intracellular signaling activation state complementing the NF-κB and myeloid activation modules in this batch neighborhood.
Genes
B3GNT5, ETS2, GK, ICAM1, LCP2, PDE4B, SKIL, ZNF267
Most correlated modules
- NF-κB Activation · correlation 0.87
- NF-κB Signaling · correlation 0.85
- NF-κB Inflammatory Transcription · correlation 0.82
- Inflammatory Resolution · correlation 0.81
- Inflammasome IL-1 Response · correlation 0.80
- Myeloid Inflammatory Activation · correlation 0.78
- C5aR Complement Activation · correlation 0.70
- Immediate Early Response · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.