Actin Cytoskeletal Remodeling
Gene co-expression module in Neutrophils
| Category | Cytoskeletal |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 18 genes have a known function matching the annotation |
Why this annotation
This module is a tightly co-regulated (core coherence) set of 18 genes uniformly expressed across neutrophil subsets. The hub genes and members collectively point to cytoskeletal regulation and actin dynamics: ARHGAP15 (Rho GTPase-activating protein), ACAP2 (Arf GAP regulating actin/membrane), SSH2 (slingshot phosphatase activating cofilin for actin depolymerization), DOCK8 (dedicator of cytokinesis, actin-mediated migration), RALGAPA2 (Ral GTPase regulation), and PRKCB (PKC-beta, regulating cytoskeletal reorganization). COP1 is an E3 ubiquitin ligase that regulates signaling; PPP3CA (calcineurin catalytic subunit) regulates cytoskeletal dynamics and migration via dephosphorylation; PELI2 is a Pellino E3 ligase involved in innate immune signaling; SH3KBP1 links receptor signaling to cytoskeletal remodeling; PTPRJ is a receptor tyrosine phosphatase regulating integrin signaling and migration; MKLN1 (muskelin) is an actin-associated protein. KDM2A, CUX1, MED13L, PAN3, RC3H1, and DPYD are more peripheral but DPYD (pyrimidine catabolism) and RC3H1 (Roquin, mRNA stability) may regulate post-transcriptional aspects of this resting neutrophil program. Taken together, the dominant signal is cytoskeletal remodeling and GTPase-mediated actin organization, consistent with neutrophil migration and shape change regulation in a homeostatic context. The neighbor modules (M19, M48) also show uniform, low-to-moderate expression and regulatory/signaling gene content, consistent with a shared homeostatic/regulatory neighborhood.
Genes
ACAP2, ARHGAP15, COP1, CUX1, DOCK8, DPYD, KDM2A, MED13L, MKLN1, PAN3, PELI2, PPP3CA, PRKCB, PTPRJ, RALGAPA2, RC3H1, SH3KBP1, SSH2
Most correlated modules
- Cytoskeletal Remodeling · correlation 0.99
- ELMO-DOCK Chemotaxis · correlation 0.98
- Stress Kinase Signaling · correlation 0.98
- Endosomal Vesicle Trafficking · correlation 0.96
- Signal Attenuation · correlation 0.96
- JAK-MAPK Signaling · correlation 0.96
- Ubiquitin-Proteasome Turnover · correlation 0.94
- ER Stress Response · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.