IFN-gamma response
Gene co-expression module in Neutrophils
| Category | Inflammatory |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 18 of 27 genes have a known function matching the annotation |
Why this annotation
This tightly co-expressed module is led by GBP1, GBP5, APOL1/2/6, TAP1, CD274 (PD-L1), FCGR1A (CD64), SAMD9/9L and IRF7. The GBP, CD274 and FCGR1A signature indicates IFN-gamma activation of neutrophils, as seen in inflamed colon (e.g., IBD). IFIT2/3 and IRF7 add type I overlap. FCGR1A and CD274 induction marks an activated, immunomodulatory neutrophil state.
Genes
Most correlated modules
- IFN-gamma response · correlation 0.89
- Interferon-stimulated genes · correlation 0.88
- Cytosolic nucleic-acid sensing · correlation 0.86
- GM-CSF Cytokine Priming · correlation 0.83
- Cytokine feedback regulation · correlation 0.82
- Type I Interferon · correlation 0.78
- Interferon-stimulated Genes · correlation 0.73
- Ubiquitin-proteasome system · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.