Type I Interferon
Gene co-expression module in Neutrophils
| Category | Antiviral |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 20 of 24 genes have a known function matching the annotation |
Why this annotation
This is the canonical type I interferon signature: MX1, RSAD2, IFI6, IFI44/IFI44L, OAS3, OASL, ISG15, HERC5, IFIT1/5, CMPK2, STAT2, EIF2AK2, XAF1, ZBP1 and DDX60, all with core membership. It forms the classical antiviral ISG arm alongside the IFN-gamma-biased neighbor M79.
Genes
Most correlated modules
- Interferon-stimulated genes · correlation 0.84
- IFN-gamma response · correlation 0.78
- IFN-gamma response · correlation 0.64
- Cytokine feedback regulation · correlation 0.64
- Cytosolic nucleic-acid sensing · correlation 0.58
- Low-level housekeeping · correlation 0.49
- GM-CSF Cytokine Priming · correlation 0.46
- Ubiquitin-proteasome system · correlation 0.43
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.