Hypoxic TREM1 activation
Gene co-expression module in Neutrophils
| Category | Tissue adaptation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 17 genes have a known function matching the annotation |
Why this annotation
Genes cover several arms of tissue activation in inflamed mucosa: - Hypoxia: HIF1A. - Myeloid activation receptors and adaptors: TREM1, C3AR1, LCP2, PIK3AP1. - Adhesion: CD44. - Chemokine: CXCL16. - Transcription factors: EGR3, ZEB2. - Granule proteoglycan: SRGN. Together this indicates a hypoxia-adapted, TREM1-driven inflammatory neutrophil state typical of colitis. It complements M70 (receptor and metabolic activation) and M89 (CXCL8 early response).
Genes
Most correlated modules
- TLR/cytokine receptor activation · correlation 0.77
- Immediate early/CXCL8 response · correlation 0.77
- TLR-NFkB signaling · correlation 0.71
- cAMP-CREB stress response · correlation 0.67
- Tissue-activated neutrophil · correlation 0.66
- Endolysosomal trafficking · correlation 0.65
- ER stress autophagy · correlation 0.60
- NF-kB/TBK1 activation · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.