Heat Shock Response
Gene co-expression module in Neutrophils
| Category | Stress |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 13 genes have a known function matching the annotation |
Why this annotation
The module is dominated by heat shock proteins: HSP90AB1, HSP90AA1, HSPA1A, HSPA6, and the co-chaperone DNAJA1, making it a clear proteotoxic/heat shock stress response module. Supporting genes include UBC (ubiquitin C, part of protein quality control), HMOX1 (heme oxygenase-1, oxidative/stress response), DUSP2 (dual-specificity phosphatase, stress-induced MAP kinase regulation), IFI30 (lysosomal thiol reductase, also stress-responsive), ATP6V0C (vacuolar ATPase subunit, proton pump for endo-lysosomal function), RNASEK (an acid pH-dependent RNase associated with V-ATPase), and CYB5D1 (cytochrome b5 domain). The cluster of HSPs and UBC clearly defines this as a heat shock/proteostasis stress response. GNG10 (G-protein subunit) is a weaker fit. The module is coherent and uniformly expressed across subsets, consistent with a stress-activated program present in a subset of neutrophils.
Genes
ATP6V0C, CYB5D1, DNAJA1, DUSP2, GNG10, HMOX1, HSP90AA1, HSP90AB1, HSPA1A, HSPA6, IFI30, RNASEK, UBC
Most correlated modules
- CC Chemokine Secretion · correlation 0.46
- Neutrophil Survival Program · correlation 0.45
- Inflammatory Resolution · correlation 0.40
- Chemokine Secretion · correlation 0.38
- Inflammasome IL-1 Response · correlation 0.38
- Mature Neutrophil Activation · correlation 0.30
- IFN-gamma Response · correlation 0.30
- RNA Splicing · correlation 0.25
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.