Cytokine-induced glycolytic activation
Gene co-expression module in Neutrophils
| Category | Tissue adaptation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 17 genes have a known function matching the annotation |
Why this annotation
PFKFB3 (glycolytic switch), NFIL3, IL4R, SAMSN1, NFKBIZ and RUNX1 indicate cytokine-induced transcriptional activation of tissue neutrophils. This likely reflects a tissue-entry or cytokine-exposure state with glycolytic reprogramming. Coherence is moderate and several hubs are non-specific (TRPS1, PGS1, NSUN7), and three of the activation genes (NFKBIZ, RUNX1, FAM107B) have weak membership, so this may be a softer extension of the M24 activation program.
Genes
Most correlated modules
- Mature neutrophil identity · correlation 0.73
- Mature circulating neutrophil · correlation 0.71
- Mature antimicrobial recognition · correlation 0.71
- TLR4/LPS activation · correlation 0.68
- RNA/Chromatin Regulation · correlation 0.66
- Activated Survival Priming · correlation 0.64
- Interferon-stimulated Genes · correlation 0.60
- Rolling & formyl-peptide motility · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.