mRNA Splicing Processing

Gene co-expression module in Neutrophils

Why this annotation

Hub genes: NKTR (NK-tumor recognition, interleukin-2 receptor beta chain modifier, immune signaling), LUC7L3 (splicing factor), PNN (pinin, splicing/RNA processing), ZRANB2 (zinc finger RNA-binding protein, splicing), FBXO9 (F-box protein, ubiquitin-mediated proteolysis), PAXBP1 (PAX3-binding protein, transcription/RNA processing), VPS13C (vacuolar protein sorting, lipid transfer at membrane contacts), UGCG (UDP-glucose ceramide glucosyltransferase, glycosphingolipid synthesis), ABCA13 (ABC transporter, lipid transport), TTC14 (tetratricopeptide protein), EMB (embigin, adhesion), OGT (O-GlcNAc transferase, nutrient sensing), STOM (stomatin, lipid raft/membrane organization), SREK1 (splicing regulatory protein), ZNF207 (transcription factor/splicing), ATP2A3 (SERCA3, calcium pump), RBM25 (RNA-binding/splicing). A dominant theme here is mRNA splicing/RNA processing (LUC7L3, PNN, ZRANB2, PAXBP1, SREK1, ZNF207, RBM25), combined with lipid/membrane metabolism (UGCG, ABCA13, STOM, VPS13C). The splicing factor cluster is the most coherent sub-program. This module most likely represents a constitutive splicing/RNA processing program, possibly in a specific neutrophil maturation state.

Genes

ABCA13, ATP2A3, EMB, FBXO9, LUC7L3, NKTR, OGT, PAXBP1, PNN, RBM25, SREK1, STOM, TTC14, UGCG, VPS13C, ZNF207, ZRANB2

Most correlated modules

• Proteostasis RNA Metabolism · correlation 0.89
• Endocytic Vesicular Trafficking · correlation 0.89
• Immature Neutrophil Granule · correlation 0.85
• Myeloid Lipid Remodeling · correlation 0.81
• S-G2-M Cell Cycle · correlation 0.80
• Apoptotic Neutrophil Program · correlation 0.79
• Myeloid Maturation · correlation 0.74
• Mitotic Spindle · correlation 0.73

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.