IFN-gamma Response
Gene co-expression module in Neutrophils
| Category | Antiviral |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes GBP1 and GBP5 are guanylate-binding proteins strongly induced by interferons (IFN-gamma in particular), known for antimicrobial and antiviral functions. IFIT2 and IFIT3 are interferon-stimulated genes (ISGs) classically induced by type I and type II interferons. IFITM3 is an antiviral ISG. ISG20 is an interferon-stimulated exonuclease. IRF1 is a key IFN-gamma-responsive transcription factor. FFAR2 (free fatty acid receptor 2) is expressed on neutrophils and modulates inflammation. CCR1 is a chemokine receptor expressed on myeloid cells. SECTM1 and SCARF1 are immune-related. CARD16, TNFSF13B (BAFF) round out the picture. This module strongly represents an interferon-stimulated gene (ISG) response, most consistent with IFN-gamma signaling given GBP1/5 and IRF1 prominence.
Genes
CARD16, CCR1, FFAR2, GBP1, GBP5, IFIT2, IFIT3, IFITM3, IRF1, ISG20, SCARF1, SECTM1, TNFSF13B
Most correlated modules
- Neutrophil Survival Program · correlation 0.61
- Immediate Early Response · correlation 0.51
- Chemokine Secretion · correlation 0.51
- Myeloid Identity · correlation 0.49
- Inflammasome IL-1 Response · correlation 0.49
- Phagocytic Membrane Signaling · correlation 0.44
- NF-κB Activation · correlation 0.41
- KLF2 Survival Response · correlation 0.38
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.