Chemokine Secretion
Gene co-expression module in Neutrophils
| Category | Cytokine & chemokine secretion |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
Top hub genes include CXCL1, CXCL8, CXCL2 (potent neutrophil-recruiting chemokines), PLAU (urokinase plasminogen activator), GADD45B (stress/DNA damage response), DDIT3 (CHOP, stress transcription factor), SGK1 (stress-responsive kinase), MAFF (stress-responsive bZIP TF), IER5 (immediate-early gene), HCAR2 (hydroxycarboxylic acid receptor), PHACTR1, GLUL. The combination of CXC chemokine secretion (CXCL1/2/8) with stress-response genes (GADD45B, DDIT3, MAFF, SGK1) and immediate-early genes (IER5) points to an inflammatory activation/stress state in neutrophils with chemokine production. This is an inflammatory activation program characterized by autocrine/paracrine chemokine secretion. The low pct positive (22.4%) suggests a subset of activated neutrophils.
Genes
CXCL1, CXCL2, CXCL8, DDIT3, GADD45B, GLUL, HCAR2, IER5, MAFF, PHACTR1, PLAU, SGK1
Most correlated modules
- Inflammasome IL-1 Response · correlation 0.79
- Neutrophil Survival Program · correlation 0.77
- CC Chemokine Secretion · correlation 0.70
- Inflammatory Resolution · correlation 0.62
- Immediate Early Response · correlation 0.56
- NF-κB Activation · correlation 0.54
- IFN-gamma Response · correlation 0.51
- Neutrophil Adhesion Signaling · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.