JAK-MAPK Signaling
Gene co-expression module in Neutrophils
| Category | Inflammatory |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
MAPK1 (ERK2) and JAK2 are central kinases in cytokine receptor signaling (JAK-STAT and MAPK cascades). GIT2 (GIT/PIX scaffold) coordinates signaling between cytokine and adhesion receptors. ENTPD1 (CD39) modulates purinergic signaling and inflammatory tone. CELF2 and MBNL1 are RNA-binding proteins that regulate alternative splicing of signaling transcripts. UTRN (utrophin) links cytoskeletal and signaling programs. This module reflects JAK-MAPK cytokine signaling in neutrophils, with co-regulated RNA splicing programs.
Genes
CELF2, ENTPD1, GIT2, JAK2, MAPK1, MBNL1, SLMAP, SPTLC2, TLE4, UTRN
Most correlated modules
- ELMO-DOCK Chemotaxis · correlation 0.97
- Signal Attenuation · correlation 0.96
- Actin Cytoskeletal Remodeling · correlation 0.96
- Stress Kinase Signaling · correlation 0.95
- Degranulation Trafficking · correlation 0.94
- Cytoskeletal Remodeling · correlation 0.93
- Granulopoiesis Program · correlation 0.92
- Ubiquitin-Proteasome Turnover · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.