Chromatin Remodeling
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 25 genes have a known function matching the annotation |
Why this annotation
Hub genes BPTF, ATRX, KDM5A, PHF3, SHPRH, and INO80D are all involved in chromatin remodeling and epigenetic regulation. CDK13 is a transcription-associated kinase. PCM1 and AKAP9 are centrosomal but peripheral. The dominant program is chromatin remodeling/epigenetic maintenance. All genes show weak membership and uniform expression, consistent with a loosely co-regulated housekeeping chromatin program. Neighbor M76 also features chromatin remodeling genes, reinforcing this interpretation.
Genes
Most correlated modules
- Chromatin & Ubiquitin · correlation 0.93
- Centrosome Organization · correlation 0.90
- RNA Processing Regulation · correlation 0.88
- pDC Identity & Splicing · correlation 0.87
- Mixed Regulatory Background · correlation 0.86
- Mixed Regulatory Background · correlation 0.85
- DNA Repair Housekeeping · correlation 0.85
- Polycomb Transcription · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.