Genome Organization
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 21 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Hub genes include TGOLN2 (trans-Golgi network protein, vesicular trafficking), RAD21 (cohesin complex, chromosome cohesion), HYOU1 (ER stress chaperone/UPR), CCP110 (centriole/centrosome), TOP2B (topoisomerase II beta, DNA topology), SLFN11 (antiviral/DNA damage response), MAP1A (microtubule-associated), RRBP1 (ER membrane/ribosome receptor), DCTN1 (dynactin, cytoskeletal motor), CTCF (chromatin insulator/genome organization), PAPOLA (poly-A polymerase), BOD1L1 (DNA damage/replication). The module is highly heterogeneous. The top hub TGOLN2 points to Golgi/vesicular trafficking, and HYOU1/RRBP1 suggest ER involvement. RAD21, TOP2B, CTCF, BOD1L1 suggest genome organization. No single tight program; the loosest unifying theme across the most genes is genome/chromatin organization and ER-Golgi trafficking. Given the neighbor context of similarly weak housekeeping modules, this is best classified as a mixed housekeeping module with a genome organization thread.
Genes
Most correlated modules
- ER Quality Control · correlation 0.91
- RNA Processing Regulation · correlation 0.88
- Ubiquitin-Proteasome Regulation · correlation 0.86
- Chromatin Remodeling · correlation 0.81
- RNA Processing · correlation 0.80
- Chromatin & Ubiquitin · correlation 0.79
- DNA Repair & Chromatin · correlation 0.77
- Transcriptional Coactivation · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.