Mixed Regulatory Background
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 33 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. The gene list includes: IREB2 (iron response element binding), CUL5 (E3 ubiquitin ligase), KMT2A (histone H3K4 methyltransferase), MAPK14 (p38 MAPK), NUP43 (nuclear pore), GOLGA8A (Golgi), MTMR4 (phosphatase), KIDINS220 (kinase substrate), FBXO42 (F-box protein/ubiquitin), RNF216 (E3 ubiquitin ligase), NPEPPS (aminopeptidase), TOGARAM1 (cilia/microtubule). No coherent single program is identifiable. The module is a weakly co-expressed, heterogeneous collection of regulatory and housekeeping genes. Similar to M41, this appears to be a background/technical module driven by co-variation in lowly expressed large genes rather than a specific biological program. Neighbor context with M41 supports this interpretation.
Genes
Most correlated modules
- Mixed Regulatory Background · correlation 0.90
- Mixed Regulatory Background · correlation 0.88
- Chromatin Remodeling · correlation 0.86
- Polycomb Transcription · correlation 0.84
- ARF-mediated Trafficking · correlation 0.84
- DNA Damage Response · correlation 0.83
- RNA Processing Regulation · correlation 0.82
- Centrosome Organization · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.