Chromatin & Ubiquitin
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 18 genes have a known function matching the annotation |
Why this annotation
Hub genes include UBE3A and TRIP12 (E3 ubiquitin ligases), BAZ2A/BAZ1B (chromatin remodeling/ISWI complex), SETX (RNA-DNA helicase, transcription-coupled repair), WAPL (cohesin release), RIF1 (replication timing/DNA repair), and TNKS2 (tankyrase/PARylation). All genes show weak membership and uniform expression, suggesting a loosely co-regulated housekeeping program centered on chromatin organization, ubiquitin-mediated protein regulation, and genome maintenance. No strong pDC-specific signal. Neighbor modules similarly show weak, uniform housekeeping programs.
Genes
Most correlated modules
- Chromatin Remodeling · correlation 0.93
- DNA Repair Housekeeping · correlation 0.89
- Chromatin RNA Regulation · correlation 0.88
- Centrosome Organization · correlation 0.87
- Centrosome DNA Damage · correlation 0.87
- RNA Processing · correlation 0.85
- Actin Cytoskeleton · correlation 0.83
- pDC Identity & Splicing · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.