ER Protein Folding
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes LMAN1, DNAJC3, TRAM1, TMED10, SPCS3, MLEC, ERLEC1, PDIA4, SEC62, and MESD all function in ER protein translocation, folding, and quality control (ER lectins, chaperones, signal peptidase, translocon components, PDI family). This is a canonical ER proteostasis/UPR-adjacent program. JAK1, POLE3, TCEA1, SMU1 are peripheral. All genes show weak membership and uniform expression, but the biological theme is tight. Neighbor M42 shares COPB2 (COPI trafficking), consistent with ER-Golgi secretory pathway co-regulation.
Genes
Most correlated modules
- Cell Cycle Regulation · correlation 0.92
- Transcriptional Regulation · correlation 0.89
- Monocyte Chemotaxis · correlation 0.89
- Clathrin-mediated Endocytosis · correlation 0.87
- Endosomal Trafficking · correlation 0.85
- Ubiquitin Proteasome · correlation 0.85
- pDC Identity · correlation 0.85
- Actin Cytoskeleton · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.