pDC Identity & Splicing
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 7 of 35 genes have a known function matching the annotation |
Why this annotation
Top hub genes include LUC7L3 (U1 snRNP splicing factor), SF1 (branch point splicing factor), SREK1 (splicing regulatory factor), KHDC4 (KH domain RNA binding). Also contains IKZF1 (Ikaros, master pDC transcription factor) and ZEB2 (pDC identity TF), NUMB (Notch pathway), MYO9B (myosin IXB, migration), VPS53 (vesicle tethering). The splicing factor component is the largest coherent sub-theme. IKZF1 and ZEB2 may reflect pDC identity co-expression. Weak membership throughout suggests a loosely resolved module mixing splicing housekeeping with pDC developmental TFs.
Genes
Most correlated modules
- RNA Processing · correlation 0.90
- Chromatin Remodeling · correlation 0.87
- Chromatin Remodeling · correlation 0.85
- Actin Cytoskeleton · correlation 0.84
- Polycomb Transcription · correlation 0.83
- Chromatin & Ubiquitin · correlation 0.83
- RNA Splicing Regulation · correlation 0.81
- Transcription Regulation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.