Chromatin Remodeling
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 8 of 23 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. Hub genes include RSF1 (chromatin remodeling factor, ISWI complex), MLXIP (MondoA, transcription factor), ARID4A and ARID1A (SWI/SNF chromatin remodeling complex subunits), ZNF292 (zinc finger transcription factor), TCERG1 (transcription elongation regulator), and REV1 (DNA repair, translesion synthesis). There is a loose theme of chromatin remodeling and transcriptional regulation (SWI/SNF complex via ARID1A/ARID4A, RSF1), but the weak membership of all genes and the heterogeneous gene content indicate a poorly defined residual module. The neighbor context of similarly weak modules in this batch confirms this is a background co-expression artifact.
Genes
Most correlated modules
- RNA Processing · correlation 0.88
- pDC Identity & Splicing · correlation 0.85
- Epigenetic Regulation · correlation 0.84
- Transcription Regulation · correlation 0.83
- RNA Splicing Regulation · correlation 0.81
- Mixed Housekeeping · correlation 0.81
- Mixed Regulatory · correlation 0.78
- JAK-STAT Signaling · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.