Transcription Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 8 of 17 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression across subsets with unknown coherence, indicating a poorly defined module. Hub genes include AFF4 (super elongation complex), JMJD1C (histone demethylase), CHD2 (chromatin remodeler), CCNT1 (Cyclin T1, transcription elongation), TRIM28 (transcriptional corepressor), and MEF2D (transcription factor). The loose theme is transcriptional elongation and chromatin regulation, but the weak membership of all genes and uniform expression suggest this is a low-coherence residual module capturing background co-variation in broadly expressed regulatory genes rather than a specific biological program.
Genes
Most correlated modules
- RNA Splicing Regulation · correlation 0.84
- Chromatin Remodeling · correlation 0.83
- RNA Processing · correlation 0.79
- Transcriptional Regulation · correlation 0.79
- Mixed Regulatory · correlation 0.78
- Mixed Housekeeping · correlation 0.77
- pDC Identity & Splicing · correlation 0.77
- Chromatin Remodeling · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.