Chemokine Migration Response
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 21 genes have a known function matching the annotation |
Why this annotation
RGS1 and RGS2 regulate G-protein coupled receptor signaling downstream of chemokines; CXCR4 and GPR183 are chemokine receptors directing cell migration. JUNB, JUND are AP-1 TFs co-induced with chemokine signaling. SOCS3 suppresses cytokine signaling. NFKBID modulates NF-κB. ZFP36 destabilizes inflammatory mRNAs. MCL1 and PIM2 promote survival. CDKN1A indicates cell cycle arrest. PFKFB3 drives glycolysis supporting activation. SEMA7A is involved in immune cell migration. AREG is an activation-induced growth factor. This module reflects a chemokine-driven migratory and survival response in activated pDCs, neighboring M1's activation program.
Genes
Most correlated modules
- pDC Activation Response · correlation 0.96
- TGF-beta Survival · correlation 0.91
- Autophagy Cytoskeletal · correlation 0.90
- Heat Shock Response · correlation 0.88
- RNA Processing · correlation 0.80
- Stress & Apoptotic Priming · correlation 0.80
- Transcriptional Regulation · correlation 0.79
- DC Maturation Migration · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.