RNA Processing
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 7 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include POLR2A (RNA polymerase II largest subunit), CLK1 (CDC-like kinase, splicing regulation), NOP58 (box C/D snoRNP, ribosome biogenesis), DDB1 (DNA damage binding/CRL4 ubiquitin ligase), CENPC (centromere protein C, kinetochore), ZBTB18/ZBTB1 (transcriptional repressors), NFKBIZ (IκBζ, NF-κB modulator). The presence of POLR2A, CLK1, NOP58, and DDB1 points to a general transcription/RNA processing housekeeping program. All genes show weak membership and uniform expression, indicating a poorly defined mixed module.
Genes
Most correlated modules
- NF-κB Immune Signaling · correlation 0.88
- Glucocorticoid Receptor · correlation 0.88
- Transcriptional Regulation · correlation 0.87
- Autophagy Cytoskeletal · correlation 0.86
- TGF-beta Survival · correlation 0.84
- Chemokine Migration Response · correlation 0.80
- pDC Innate Sensing · correlation 0.80
- Transcriptional Repression · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.