Low-coherence Background
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 19 of 29 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. The gene set includes AEBP2 (PRC2 complex/chromatin), SP4 (transcription factor), ZNF544/ZNF708/ZNF680/ZNF141 (zinc finger transcription factors), KAT7 (histone acetyltransferase), ASCC3 (DNA repair/transcription), AP3B1 (AP-3 adaptor/vesicle trafficking), RNF19A (E3 ubiquitin ligase), USP33 (deubiquitinase), CDC16 (APC/C complex/cell cycle), MAPKAP1 (mTORC2), RHOT1 (mitochondrial Rho GTPase), MTERF1 (mitochondrial transcription termination), GSTM2 (glutathione S-transferase), API5 (apoptosis inhibitor), LONP2 (peroxisomal protease), KIZ (centrosome). The module is highly heterogeneous with transcription factors, chromatin regulators, ubiquitin pathway, and mitochondrial genes. No single program dominates; this is a low-coherence background module.
Genes
Most correlated modules
- Low-coherence Background · correlation 0.92
- Low-coherence Background · correlation 0.92
- Low-coherence Background · correlation 0.87
- Low-coherence Background · correlation 0.87
- Mixed Regulatory Background · correlation 0.85
- Intracellular Kinase Signaling · correlation 0.84
- DNA Damage Response · correlation 0.83
- Low-coherence Background · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.