Low-coherence Background
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. Notable genes: NRIP1 (nuclear receptor corepressor/RIP140), PTEN (tumor suppressor/PI3K-AKT), CUL3 (cullin E3 ubiquitin ligase), E2F5 (cell cycle transcription factor), TCF20 (transcriptional coactivator), ZFR (RNA binding), SLC16A7 (monocarboxylate transporter), MTREX (RNA exosome/nuclear RNA surveillance), SCAF4 (splicing), PRKD3 (protein kinase D), BET1 (SNARE/vesicle), ODR4 (transmembrane), XRRA1 (X-ray radiation resistance). The module is heterogeneous with partial signals for transcriptional regulation (NRIP1, E2F5, TCF20, CUL3) and RNA processing (ZFR, MTREX, SCAF4). No single program dominates; low-coherence background.
Genes
Most correlated modules
- Low-coherence Background · correlation 0.92
- Low-coherence Background · correlation 0.85
- Low-coherence Background · correlation 0.83
- Low-coherence Background · correlation 0.82
- Actin Cytoskeleton · correlation 0.80
- Low-coherence Background · correlation 0.79
- Polycomb Transcription · correlation 0.77
- Mixed Housekeeping · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.