Low-coherence Background
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 10 of 19 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. The gene set includes MGA (MYC-associated factor X/transcription), TAB2 (TGF-beta/NF-kB signaling adaptor), BMPR2 (BMP receptor/TGF-beta superfamily), ZMYND8 (chromatin/transcription), ASXL2 (Polycomb/chromatin), APC (Wnt pathway tumor suppressor), EXOC1 (exocyst complex/vesicle), RBM26 (RNA binding), DGKE (diacylglycerol kinase), MAN2A1 (Golgi/glycosylation), TNRC6A (miRNA-mediated silencing/GW182), LARP4 (RNA binding), TAOK3 (MAP3K/stress kinase), RNF169 (DNA damage/ubiquitin). The module is functionally heterogeneous. There is a partial signal for chromatin/transcriptional regulation (MGA, ZMYND8, ASXL2, APC) and RNA processing (RBM26, TNRC6A, LARP4), but no single program dominates. Low-coherence background module.
Genes
Most correlated modules
- Low-coherence Background · correlation 0.94
- Low-coherence Background · correlation 0.92
- Low-coherence Background · correlation 0.91
- Low-coherence Background · correlation 0.87
- Cilia & Centrosome · correlation 0.86
- Intracellular Kinase Signaling · correlation 0.85
- Low-coherence Background · correlation 0.85
- Autophagy & Proteostasis · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.