Low-coherence Background
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. The gene set includes PHF21A (PHD finger/chromatin), ALMS1 (ciliopathy/centrosome), HERC1 (large HECT E3 ubiquitin ligase), PICALM (clathrin-mediated endocytosis), KLF12 (Krüppel-like transcription factor), FBXL20 (F-box/ubiquitin), BRWD3 (bromodomain/chromatin), PIBF1 (progesterone-induced blocking factor/cilia), RASA2 (RAS GAP), PUM2 (RNA-binding/translational repressor). The mix of chromatin regulators, ubiquitin pathway, cilia-associated, and RNA-binding genes with all-weak memberships and no coherence signal indicates a poorly defined background module. No single program is dominant.
Genes
Most correlated modules
- Intracellular Kinase Signaling · correlation 0.92
- Low-coherence Background · correlation 0.91
- Low-coherence Background · correlation 0.91
- Low-coherence Background · correlation 0.90
- Cilia & Centrosome · correlation 0.88
- Low-coherence Background · correlation 0.87
- Kinase Phosphatase Signaling · correlation 0.83
- Low-coherence Background · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.