Low-coherence Background
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 14 of 14 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression across subsets, with unknown coherence. The gene set is functionally heterogeneous: SMARCC1 (chromatin remodeling/SWI-SNF), TFDP2 (transcription factor/E2F partner), THOC1 (mRNA export/THO complex), KPNA5 (nuclear import), SEC23A (COPII vesicle/ER-to-Golgi), ORC2 (DNA replication origin), NCOA3 (transcriptional coactivator), SOS2 (RAS GEF), ADAM17 (metalloprotease/shedding), PPP2R5E (phosphatase regulatory subunit), ATXN3 (deubiquitinase), SLC7A6 (amino acid transporter), MYO9A (myosin), STRBP (RNA binding). No single coherent biological program dominates. The mix of nuclear transport, chromatin, vesicle trafficking, and signaling genes with all-weak memberships and unknown coherence is characteristic of a poorly defined, low-coherence technical/housekeeping background module rather than a specific biological program. The neighbor context (all modules in this batch share the same weak-membership, uniform-expression profile) supports a technical/background interpretation.
Genes
Most correlated modules
- Low-coherence Background · correlation 0.94
- Low-coherence Background · correlation 0.92
- Low-coherence Background · correlation 0.90
- Low-coherence Background · correlation 0.88
- Low-coherence Background · correlation 0.87
- Cilia & Centrosome · correlation 0.83
- Mixed Housekeeping · correlation 0.82
- Polycomb Transcription · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.