Intracellular Kinase Signaling
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 7 of 22 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression across subsets, with unknown coherence. The gene set is highly heterogeneous: MAP3K3 (MEKK3, stress/inflammatory kinase), MLKL (necroptosis executor), BLM (DNA helicase/repair), ABL2 (tyrosine kinase), MINK1 (misshapen-like kinase), PPP1R12B (myosin phosphatase), GDI1 (Rab GTPase regulator), DENND1A (DENN domain vesicle trafficking), DOCK11 (Rho GEF). No coherent single program emerges. The module appears to be a weakly correlated catch-all of signaling and regulatory genes. The presence of MAP3K3, MLKL, MINK1, and TRAF-pathway-adjacent kinases hints at a loose stress/cell death signaling theme, but the evidence is insufficient for a tight label. Given the neighbor context of similarly weak, uniform modules, this batch likely represents low-coherence background modules. The best supported theme across hub genes is broad intracellular signaling/kinase activity.
Genes
Most correlated modules
- Low-coherence Background · correlation 0.92
- Cilia & Centrosome · correlation 0.90
- Kinase Phosphatase Signaling · correlation 0.86
- Low-coherence Background · correlation 0.85
- Low-coherence Background · correlation 0.84
- Low-coherence Background · correlation 0.82
- Low-coherence Background · correlation 0.80
- Stress Kinase Signaling · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.