DNA Damage Response
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 22 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Notable genes: LATS1 (large tumor suppressor kinase 1, Hippo pathway), TP53BP1 (p53-binding protein, DNA damage response), SLF2 (SMC5/6 loading factor, DNA repair), ZGRF1 (zinc finger GRF-type, DNA repair/replication), CEP192 (centrosome protein, centriole duplication), NUP205 (nucleoporin, nuclear pore), CNOT6 (CCR4-NOT deadenylase complex), SENP7 (SUMO protease), MARF1 (meiosis arrest female 1, RNA regulation), EXTL3 (heparan sulfate biosynthesis). Several genes relate to DNA damage response and genome maintenance (LATS1, TP53BP1, SLF2, ZGRF1, CEP192). This loosely suggests a DNA damage/genome integrity program, but coherence is weak and the module is heterogeneous.
Genes
Most correlated modules
- Mixed Regulatory Background · correlation 0.87
- Autophagy & Proteostasis · correlation 0.86
- Kinase Phosphatase Signaling · correlation 0.84
- Low-coherence Background · correlation 0.83
- Intracellular Kinase Signaling · correlation 0.78
- Low-coherence Background · correlation 0.76
- Mixed Regulatory Background · correlation 0.73
- Low-coherence Background · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.