Mixed Housekeeping
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 8 of 21 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. Hub genes include SUPT6H (transcription elongation factor), TNPO1 (importin beta, nuclear transport), EIF4G1 (translation initiation factor), SIN3A (HDAC-associated transcriptional repressor), RNF168 (E3 ubiquitin ligase in DNA damage response), and SEC24D (COPII vesicle coat). This is a heterogeneous mix of nuclear transport, translation, chromatin regulation, and vesicular trafficking genes. The weak membership of all genes and uniform expression across subsets, combined with the neighbor context of similarly weak modules, indicates this is a low-coherence residual housekeeping module with no coherent single biological program.
Genes
Most correlated modules
- Transcriptional Regulation · correlation 0.83
- RNA Splicing Regulation · correlation 0.81
- Chromatin Remodeling · correlation 0.81
- Epigenetic Regulation · correlation 0.80
- RNA Processing · correlation 0.78
- RNA Processing · correlation 0.77
- Transcription Regulation · correlation 0.77
- Glucocorticoid Receptor · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.