Glucocorticoid Receptor
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 27 genes have a known function matching the annotation |
Why this annotation
Hub genes include RALGAPA1 (RalGAP, Ral GTPase regulation), RAB20 (vesicular trafficking), NR3C1 (glucocorticoid receptor, a key transcription factor for steroid hormone response), HOMER1 (postsynaptic scaffold/calcium signaling), FADS2 (fatty acid desaturase 2, lipid metabolism), USP38/USP11 (deubiquitinases), ERF (ETS2 repressor factor). NR3C1 links this module to M68 (TSC22D3/DDIT4 glucocorticoid response) as a topological neighbor, suggesting shared glucocorticoid signaling context. However, the module is highly mixed with vesicular, lipid, and ubiquitin themes. All genes show weak membership.
Genes
Most correlated modules
- RNA Processing · correlation 0.88
- NF-κB Immune Signaling · correlation 0.84
- Autophagy Cytoskeletal · correlation 0.83
- Transcriptional Regulation · correlation 0.82
- TGF-beta Survival · correlation 0.82
- pDC Activation Response · correlation 0.81
- Chemokine Migration Response · correlation 0.77
- Mixed Housekeeping · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.