Transcriptional Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 9 of 22 genes have a known function matching the annotation |
Why this annotation
Genes include BRD4 (bromodomain transcriptional coactivator), FOXO3 (forkhead transcription factor, stress/longevity), IL6ST (gp130 cytokine receptor subunit), SMG1 (PI3K-like kinase in NMD), ARID4B (chromatin remodeling), CPEB4 (RNA-binding, translational control), ZBTB10 (transcriptional repressor), TFRC (transferrin receptor, iron uptake). All genes show weak membership and uniform expression. The module is poorly defined but has a thread of transcriptional and post-transcriptional regulation. No tight single program is evident.
Genes
Most correlated modules
- RNA Processing · correlation 0.87
- Autophagy Cytoskeletal · correlation 0.84
- TGF-beta Survival · correlation 0.84
- NF-κB Immune Signaling · correlation 0.84
- Mixed Housekeeping · correlation 0.83
- Glucocorticoid Receptor · correlation 0.82
- Mixed Regulatory · correlation 0.82
- RNA Splicing Regulation · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.