Epigenetic Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 7 of 19 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. Hub genes include INPP4A (inositol phosphatase, PI signaling), MAP3K2 (MAPK kinase kinase), CDYL (chromodomain protein, epigenetic reader), SETD5 (histone H3K4 methyltransferase), KAT2B (histone acetyltransferase), TET2 (DNA demethylase, important in hematopoietic cells including pDCs), and FLNB (filamin B, cytoskeletal). TET2 is notable as a key epigenetic regulator in pDCs and myeloid cells, but the weak membership of all genes and the heterogeneous mix of epigenetic, signaling, and cytoskeletal genes indicate a poorly defined residual module. The neighbor context of similarly weak modules supports a technical/background interpretation.
Genes
Most correlated modules
- Chromatin Remodeling · correlation 0.84
- Mixed Regulatory · correlation 0.82
- Polycomb Transcription · correlation 0.81
- Mixed Housekeeping · correlation 0.80
- RNA Processing · correlation 0.78
- Chromatin Regulation · correlation 0.78
- Transcription Regulation · correlation 0.75
- Transcriptional Regulation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.