DC Maturation Migration
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
CCR7 is the canonical lymph node homing receptor upregulated upon DC maturation. CD40 is a co-stimulatory receptor critical for DC-T cell interaction and DC maturation. BCL2A1 and BIRC3 are anti-apoptotic genes induced during DC activation to promote survival. TNFRSF4 (OX40) is expressed on activated immune cells. FSTL3 is a TGF-beta antagonist. GPR132 is a stress-sensing GPCR. DUSP4 is a phosphatase in immune signaling. This module represents a pDC maturation program with lymph node migration (CCR7), survival (BCL2A1, BIRC3), and co-stimulatory capacity (CD40). Neighbor context with M1 and M124 supports a coordinated activation-maturation program.
Genes
Most correlated modules
- pDC Activation Response · correlation 0.84
- Heat Shock Response · correlation 0.83
- Chemokine Migration Response · correlation 0.78
- Stress & Apoptotic Priming · correlation 0.71
- Autophagy Cytoskeletal · correlation 0.66
- NF-κB Immune Signaling · correlation 0.66
- pDC Innate Sensing · correlation 0.66
- Type I Interferon · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.