Mixed Regulatory
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 9 of 19 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression with unknown coherence. Notable hub genes include CIITA (master regulator of MHC class II antigen presentation, highly relevant to pDCs and DCs), CREBBP (transcriptional coactivator), ASH1L (histone H3K4 methyltransferase), MED13 (Mediator complex subunit), and COPA/GOLGA4/SEC16A (COPI/Golgi vesicular trafficking). CIITA is a key pDC/DC gene involved in antigen presentation, but the weak membership of all genes and the heterogeneous mix of chromatin, transcription, and vesicular trafficking genes suggest this is a poorly defined residual module rather than a coherent antigen presentation program. The neighbor context (all modules in this batch are weak/uniform) supports a technical artifact interpretation.
Genes
Most correlated modules
- Metabolic Stress Response · correlation 0.84
- Transcriptional Regulation · correlation 0.82
- Epigenetic Regulation · correlation 0.82
- JAK-STAT Signaling · correlation 0.82
- Chromatin Remodeling · correlation 0.78
- Transcription Regulation · correlation 0.78
- RNA Splicing Regulation · correlation 0.77
- RNA Processing Regulation · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.