Post-transcriptional Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Hub genes include MAFG (stress-responsive bZIP TF), AGO2 (miRNA-mediated gene silencing), MYO1G (immune cell cortical myosin), UBASH3B (immune receptor dephosphorylation), SWAP70 (Rac GEF in B cells/DCs), and NKG7 (cytotoxic granule marker). AGO2 and ZC3H12C (MCPIP1, RNA endonuclease) point to post-transcriptional gene regulation. The module is weakly defined but has a post-transcriptional/RNA regulatory flavor combined with immune signaling. Low certainty due to weak coherence.
Genes
Most correlated modules
- Survival & Adhesion · correlation 0.79
- Stress & Apoptotic Priming · correlation 0.73
- Glucocorticoid Stress Response · correlation 0.73
- Autophagy Cytoskeletal · correlation 0.70
- Progenitor Transcription · correlation 0.66
- Hematopoietic Development · correlation 0.64
- IFN-Vesicular Response · correlation 0.63
- Glycolytic Metabolism · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.