Kinase Phosphatase Signaling
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 19 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. Notable genes: CASK (membrane-associated guanylate kinase, synaptic scaffolding), STK3 (serine/threonine kinase, Hippo pathway), PHLPP1 (phosphatase, AKT dephosphorylation), PRKCE (protein kinase C epsilon), SYNE1 (nesprin-1, nuclear envelope/cytoskeleton), TIAM2 (Rac1 GEF, cytoskeletal), LRCH1 (leucine-rich repeats, immune cell migration), ITPKC (inositol trisphosphate kinase C, calcium signaling), FUT8 (fucosyltransferase, glycosylation), SLC9A9 (sodium-hydrogen exchanger). The module is heterogeneous with kinases, scaffolding proteins, and transporters. No tight single program. The loosest theme is broad kinase/phosphatase signaling. Given neighbor context of similarly weak modules, this is likely a background low-coherence module.
Genes
Most correlated modules
- Stress Kinase Signaling · correlation 0.92
- Intracellular Kinase Signaling · correlation 0.86
- DNA Damage Response · correlation 0.84
- Low-coherence Background · correlation 0.83
- Mixed Regulatory Background · correlation 0.77
- Autophagy & Proteostasis · correlation 0.75
- Mixed Signaling Regulation · correlation 0.74
- Mixed Maintenance Genes · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.