Metabolic Housekeeping
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
SLC1A5 (ASCT2) is a glutamine/amino acid transporter that activates mTORC1; ISCA2 is essential for mitochondrial iron-sulfur cluster assembly; IMP3 is a ribosome biogenesis factor; ADI1 is involved in methionine salvage/acireductone metabolism; ADH5 is alcohol/formaldehyde dehydrogenase (metabolic detox); ERH participates in RNA processing; MARCHF2 is an E3 ubiquitin ligase. The module is weakly coherent with no dominant pathway — a mixed metabolic/housekeeping module. Weak membership across all genes and uniform expression confirm low biological specificity.
Genes
Most correlated modules
- Clathrin-mediated Endocytosis · correlation 0.93
- Fc Receptor Trafficking · correlation 0.93
- ER-Golgi Trafficking · correlation 0.92
- Actin Cytoskeletal Remodeling · correlation 0.92
- Lysosomal mTOR Signaling · correlation 0.90
- Actin Cytoskeleton · correlation 0.89
- ER Redox Homeostasis · correlation 0.88
- ER Protein Folding · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.