ER-Golgi Trafficking
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Vesicular traficking |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
ARF5 is an ADP-ribosylation factor regulating COPI vesicle formation; COPZ1 is a COPI coatomer subunit; TMED2 is a p24 family member involved in ER-Golgi cargo selection; KDELR1 is the ER retention receptor; SPCS2 is a signal peptidase complex subunit; OSTC is part of the oligosaccharyltransferase complex in the ER; SNX3 mediates endosomal retromer sorting; ATP6AP2 is a V-ATPase accessory subunit important for endolysosomal acidification. Together these point to ER-Golgi vesicular trafficking and ER protein processing. SRSF9 (splicing) and SDHD (complex II) are peripheral members. Neighbor modules share housekeeping character.
Genes
Most correlated modules
- ER-Golgi Trafficking · correlation 0.92
- Clathrin-mediated Endocytosis · correlation 0.92
- Metabolic Housekeeping · correlation 0.92
- Lysosomal mTOR Signaling · correlation 0.91
- ER Redox Homeostasis · correlation 0.90
- General Cellular Maintenance · correlation 0.88
- Actin Cytoskeletal Remodeling · correlation 0.87
- ER Protein Folding · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.