Lysosomal mTOR Signaling
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 17 genes have a known function matching the annotation |
Why this annotation
LAMTOR1 is a core Ragulator complex component anchoring mTORC1 to lysosomes; COX7A2L is involved in mitochondrial respiratory supercomplex assembly; MRPL34 and MRPS34 are mitochondrial ribosomal proteins; EIF6 and NACA are translation-related. SUMO1 and GTF3A are general nuclear regulators. The module is weakly coherent with uniform expression — a loosely associated housekeeping module with lysosomal/mTOR and mitochondrial ribosome themes. Neighbor context (M98 mitochondrial, M173 ER trafficking) supports a general organelle housekeeping neighborhood.
Genes
Most correlated modules
- Mitochondrial Assembly · correlation 0.92
- General Cellular Maintenance · correlation 0.92
- Actin Cytoskeleton · correlation 0.91
- ER-Golgi Trafficking · correlation 0.91
- ER Redox Homeostasis · correlation 0.91
- Metabolic Housekeeping · correlation 0.90
- Fc Receptor Trafficking · correlation 0.88
- General Housekeeping · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.