Mixed Signaling Regulation
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 7 of 28 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression. The gene set is heterogeneous. Notable genes: FOXO4 (forkhead transcription factor, stress/apoptosis), RASGRP1 (RAS guanyl nucleotide-releasing protein, lymphocyte signaling), LIMK1 (actin cytoskeleton regulation), NLRP1 (inflammasome), CCL28 (chemokine), HOPX (homeodomain protein, tissue residency marker in lymphocytes), LPAR6 (lysophosphatidic acid receptor), ADAMTS6 (metalloprotease), UHRF2 (epigenetic regulator), MSI2 (RNA-binding, stem cell). No single coherent program. HOPX and RASGRP1 suggest a tissue-residency or lymphocyte-activation flavor, but the module is too heterogeneous. The weak coherence and uniform expression across all subsets suggest this is a low-quality background module. The loosest unifying theme involves signaling and transcriptional regulation.
Genes
Most correlated modules
- Autophagy & Proteostasis · correlation 0.77
- Kinase Phosphatase Signaling · correlation 0.74
- Intracellular Kinase Signaling · correlation 0.71
- Survival & Adhesion · correlation 0.70
- DNA Damage Response · correlation 0.70
- Stress Kinase Signaling · correlation 0.67
- Mixed Maintenance Genes · correlation 0.66
- Hematopoietic Development · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.