Mixed Regulatory Background
Gene co-expression module in Plasmacytoid dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 7 of 26 genes have a known function matching the annotation |
Why this annotation
All genes show weak membership and uniform expression across subsets with unknown coherence. The gene list is highly heterogeneous: FAM13B (RNA-binding), QKI (RNA-binding), MAP4K4 (kinase), NSD1 (histone methyltransferase), ZNF33A (zinc finger TF), WAC (chromatin regulator), NIPBL (cohesin loader), EHMT1 (histone methyltransferase), KMT5B (histone methyltransferase), SP3 (TF), ATF7IP (chromatin/epigenetic), CERT1 (ceramide transfer), RABEP1 (endosome trafficking), KIF13B (kinesin motor), CLCN5 (chloride channel). No coherent single biological program emerges; genes span chromatin regulation, RNA processing, signaling, and trafficking. The module has unknown coherence and all genes are weakly associated. This is a poorly defined, likely artifactual or background module with no dominant pathway. Given the mix of large, lowly expressed genes with weak co-expression, this resembles a technical/background module of large housekeeping-type genes co-varying due to cell size or capture efficiency rather than a specific biological program.
Genes
Most correlated modules
- Polycomb Transcription · correlation 0.90
- Mixed Regulatory Background · correlation 0.90
- Mixed Regulatory Background · correlation 0.90
- Actin Cytoskeleton · correlation 0.87
- ARF-mediated Trafficking · correlation 0.86
- Chromatin Remodeling · correlation 0.85
- DNA Damage Response · correlation 0.85
- Mixed Regulatory Background · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.